Expression of Tissue Inhibitors of Metalloproteinases TIMPs in Hepatocellular Carcinoma
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چکیده
منابع مشابه
Expression of Tissue Inhibitors of Metalloproteinases (TIMPs) in Hepatocellular Carcinoma
BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the remodelling of extracellular matrix (ECM), including basement membrane. ECM remodelling is associated with pathological processes, including hepatic fibrosis, tumor invasion and metastasis. Tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 were known to inhibit MMP-9 and MMP-2, respectively. In the present study, w...
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Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial collagenases and MMP-9. TIMP-2 binds specifically and noncovalently to the pro-form of MMP-2 and inhibits its enzyme activity. In this study, we examined TIMP-...
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Email: Eiji Matsumoto* [email protected]; Harushige Nakatsukasa [email protected]; Kazuhiro Nouso [email protected]; Shin-ichiro Nakamura [email protected]; Mayumi Suzuki [email protected]; Yoshiyuki Kobayashi [email protected]; Masayuki Uemura [email protected]; Syuichiro Sato [email protected]; Eiichiro Yumoto [email protected]; Junko Yokoyama agkun@...
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ژورنال
عنوان ژورنال: The Korean Journal of Internal Medicine
سال: 2000
ISSN: 1226-3303,2005-6648
DOI: 10.3904/kjim.2000.15.3.171